ZDHHC6: A Zinc Finger Protein Involved in Cell Growth, Apoptosis and Transcriptional Regulation

Target Name: ZDHHC6

NCBI ID: G64429

ZDHHC6: A Zinc Finger Protein Involved in Cell Growth, Apoptosis and Transcriptional Regulation

Zinc finger proteins (ZFPs) are a family of non-coding RNAs that play a crucial role in various cellular processes. ZDHHC6, also known as Zinc finger protein 376, is a ZFBP gene that is expressed in various tissues and cell types. ZDHHC6 has been shown to be involved in a wide range of physiological processes, including cell growth, apoptosis, and transcriptional regulation.

The ZDHHC6 gene is located on chromosome 6 and contains 211 amino acid residues. ZFPs are characterized by the presence of a zinc finger domain, which is a specific type of non-coding RNA-binding protein that consists of a variable number of amino acids that are usually fused to a specific zinc finger residue. ZFPs can also contain a C-terminal region that is involved in protein-protein interactions and a C-terminal region that can act as a transmembrane protein.

ZDHHC6 is a protein that has been shown to be involved in various cellular processes, including cell growth, apoptosis, and transcriptional regulation. For example, studies have shown that ZDHHC6 can promote cell growth and can also induce cell apoptosis. ZDHHC6 has also been shown to be involved in the regulation of gene expression, including the regulation of cell cycle progression and the regulation of apoptosis.

In addition to its role in cellular processes, ZDHHC6 has also been shown to be a potential drug target. ZDHHC6 has been shown to interact with various proteins, including the transcription factor, p53. This interaction between ZDHHC6 and p53 has been shown to play a role in the regulation of cell apoptosis.

Furthermore, ZDHHC6 has also been shown to be involved in the regulation of inflammation. ZDHHC6 has been shown to be involved in the regulation of the production of pro-inflammatory cytokines, such as TNF-alpha and IL-18. This regulation of inflammation has important implications for the development of inflammatory diseases, such as cancer and autoimmune diseases.

In conclusion, ZDHHC6 is a protein that has been shown to be involved in a wide range of cellular processes, including cell growth, apoptosis, and transcriptional regulation. ZDHHC6 has also been shown to be involved in the regulation of cell cycle progression, apoptosis, and inflammation. Given its involvement in these processes, ZDHHC6 is a potential drug target for the development of new therapeutic strategies for a wide range of diseases.

Protein Name: Zinc Finger DHHC-type Palmitoyltransferase 6

Functions: Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC (PubMed:22314232, PubMed:22728137, PubMed:25368151, PubMed:28826475). Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (PubMed:22314232). Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (PubMed:22728137). Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation (PubMed:26214738)

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