Palmitoyl Transferase ZDHHC5: A Potential Drug Target (G25921)

Target Name: ZDHHC5

NCBI ID: G25921

Palmitoyl Transferase ZDHHC5: A Potential Drug Target

Palmitoyltransferase ZDHHC5 (Probable Palmitoyl Transferase ZDHHC5) is a protein that is expressed in various tissues throughout the body. It is a key enzyme in the palmitoyl transfer system, which is a process that involves the transfer of palmitoyl groups from phospholipids to other molecules. This The enzyme is therefore considered a potential drug target (or biomarker).

The palmitoyl transfer system is a critical pathway for the synthesis of various signaling molecules, including proteins, lipids, and drugs. The transfer of palmitoyl groups is a key step in the synthesis of these molecules. In addition, the palmitoyl transfer system is also involved in the regulation of various cellular processes, including cell signaling, inflammation, and metabolism.

Palmitoyl transferase ZDHHC5 is a member of the palmitoyl transferase family 5, which includes several other enzymes that are involved in the transfer of palmitoyl groups. These enzymes belong to the subfamily of N-acyl transferases (NATs), which are a group of enzymes that are involved in the transfer of various types of acyl groups.

The function of palmitoyl transferase ZDHHC5 is to catalyze the transfer of a palmitoyl group from a phospholipid to another molecule. This transfer occurs through a series of steps, including the formation of a palmitoylating enzyme complex, the addition of the palmitoyl group to the target molecule , and the hydrolysis of the bond between the palmitoyl group and the target molecule.

Palmitoyl transferase ZDHHC5 is involved in the synthesis of various signaling molecules, including proteins, lipids, and drugs. For example, this enzyme is involved in the synthesis of the protein translocation factor N-acyl transferase (NAT), which is a key regulator of protein synthesis and degradation. In addition, this enzyme is also involved in the synthesis of various lipids, including fatty acids, which are involved in cellular signaling and energy metabolism.

The role of palmitoyl transferase ZDHHC5 in cell signaling is also of interest. This enzyme has been shown to be involved in the regulation of various cellular processes, including cell signaling, inflammation, and metabolism. For example, studies have shown that palmitoyl transferase ZDHHC5 is involved in the regulation of cell signaling, including the signaling pathways that are involved in cell growth, differentiation, and inflammation.

In addition, the palmitoyl transfer system is also involved in the regulation of various cellular processes, including cell signaling, inflammation, and metabolism. The transfer of palmitoyl groups is a key step in the synthesis of various signaling molecules, including proteins, lipids, and drugs. Therefore, the regulation of palmitoyl transferase ZDHHC5 may be a useful target for the development of new drugs or diagnostic tools.

In conclusion, palmitoyl transferase ZDHHC5 is a protein that is involved in various cellular processes that are critical for the maintenance of cellular homeostasis. The regulation of palmitoyl transferase ZDHHC5 may be a useful target for the development of new drugs or diagnostic tools. Further research is needed to fully understand the role of this enzyme in cellular processes and its potential as a drug target.

Protein Name: Zinc Finger DHHC-type Palmitoyltransferase 5

Functions: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, fatty acid uptake, bacterial sensing or cardiac functions (PubMed:21820437, PubMed:29185452, PubMed:31402609). Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins (PubMed:26334723). Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2 (PubMed:26334723). Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2 (PubMed:31402609). Plays a role in innate immune response by mediating the palmitoylation of NOD1 and NOD2 and their proper recruitment to the bacterial entry site and phagosomes (PubMed:31649195). Participates also in fatty acid uptake by palmitoylating CD36 and thereby targeting it to the plasma membrane. Upon binding of fatty acids to CD36, gets phosphorylated by LYN leading to inactivation and subsequent CD36 caveolar endocytosis (PubMed:32958780). Controls oligodendrocyte development by catalyzing STAT3 palmitoylation (By similarity)

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