ZDHHC13: A Drug Target / Disease Biomarker (G54503)

Target Name: ZDHHC13

NCBI ID: G54503

ZDHHC13: A Drug Target / Disease Biomarker

ZDHHC13 is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the Z-DNA binding protein family, which is known for their role in the regulation of gene expression and DNA replication. ZDHHC13 has been identified as a potential drug target due to its involvement in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The Z-DNA binding protein family is a large family of proteins that contain a characteristic Z-shaped domains. These domains are known to have a structural flexibility that allows them to interact with DNA in a variety of ways. ZDHHC13 is a member of this family and has been shown to play a role in the regulation of gene expression and DNA replication.

One of the key functions of ZDHHC13 is its ability to interact with DNA in a specific way. Studies have shown that ZDHHC13 can form a complex with the DNA template in a process called DNA binding, which is critical for the regulation of gene expression. This interaction between ZDHHC13 and DNA allows it to influence the expression of genes that are important for the development and progression of many diseases.

In addition to its role in gene expression, ZDHHC13 has also been shown to play a role in the regulation of DNA replication. This is important for the development and progression of cancer, as changes in DNA replication can contribute to the development of cancer cells. ZDHHC13 has been shown to play a role in regulating the DNA replication machinery in cancer cells, which may be a potential target for cancer treatments.

Another potential function of ZDHHC13 is its role in the regulation of autoimmune disorders. autoimmune disorders are a group of diseases in which the immune system attacks the body's own tissues, leading to inflammation and damage. ZDHHC13 has been shown to play a role in the regulation of immune cells, which may be a potential target for the development of treatments for autoimmune disorders.

In conclusion, ZDHHC13 is a protein that has been identified as a potential drug target due to its involvement in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its ability to interact with DNA and regulate gene expression and DNA replication makes it an attractive target for researchers and clinicians. Further studies are needed to fully understand the role of ZDHHC13 in these diseases and to develop effective treatments.

Protein Name: Zinc Finger DHHC-type Palmitoyltransferase 13

Functions: Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (By similarity). Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport

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