Identifying Potential Drug Targets and Biomarkers for ZCWPW2 (G152098)

Target Name: ZCWPW2

NCBI ID: G152098

Identifying Potential Drug Targets and Biomarkers for ZCWPW2

ZCWPW2 (ZCPW2_HUMAN), a protein found in human placenta, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Its unique structure and expression pattern make it an attractive target for researchers to investigate and develop new treatments.

ZCWPW2 is a single-pass transmembrane protein that is expressed in various tissues and organs in the human body. It is characterized by a unique topology, with a transmembrane region that is connected to the cytoskeleton and a cytoplasmic tail that extends into the cytoplasm. The protein is composed of 254 amino acids and has a calculated molecular weight of 30 kDa.

ZCWPW2 has been shown to play a crucial role in various physiological processes in the human body. It is involved in the development and maintenance of blood vessels, including the placenta, which is a vital organ that supplies oxygen and nutrients to the developing fetus. The placenta also removes waste products and provides a barrier to harmful substances, ensuring a healthy environment for the fetus.

In addition to its role in placenta development and function, ZCWPW2 has also been linked to the development and progression of various diseases. For example, it has been shown to be involved in the development of neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. These disorders are characterized by the progressive loss of brain cells and the accumulation of waste products, leading to a decline in cognitive and motor function.

ZCWPW2 has also been linked to the development and progression of cancer, including breast, ovarian, and prostate cancers. These cancers are characterized by the formation of tumors, which can invade and destroy nearby cells, leading to their rapid growth and progression.

The unique expression pattern of ZCWPW2 in various tissues and organs makes it an attractive target for researchers to investigate and develop new treatments. By blocking the function of ZCWPW2, researchers can potentially reduce the growth and progression of cancer cells, improve the function of the placenta, and treat neurodegenerative disorders.

In addition to its potential therapeutic applications, ZCWPW2 also has the potential to serve as a biomarker for various diseases. The expression and distribution of the protein across different tissues and organs make it a valuable diagnostic tool for researchers to study the effects of drugs on various biological processes. By analyzing the expression patterns of ZCWPW2, researchers can gain insights into the mechanisms of disease progression and the potential benefits of new treatments.

In conclusion, ZCWPW2 is a protein that has the potential to serve as a drug target and biomarker for various diseases. Its unique structure and expression pattern make it an attractive target for researchers to investigate and develop new treatments. As further research continues to uncover the functions of ZCWPW2, its potential as a therapeutic and diagnostic tool is sure to grow.

Protein Name: Zinc Finger CW-type And PWWP Domain Containing 2

Functions: Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034)

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