Understanding ZBTB7A: Potential Drug Target Or Biomarker (G51341)

Target Name: ZBTB7A

NCBI ID: G51341

Understanding ZBTB7A: Potential Drug Target Or Biomarker

ZBTB7A, also known as POZ and Krueppel erythroid myeloid ontogenic factor (EMIF), is a protein that is expressed in the erythroid gland and is involved in the development and maintenance of normal thyroid function. ZBTB7A has also been shown to play a role in the development and progression of various diseases, including cancer. As a result, ZBTB7A has potential as a drug target or biomarker.

The Importance of ZBTB7A

ZBTB7A is a key regulator of erythroid development and function. It is a transcription factor that is involved in the regulation of gene expression and has been shown to play a role in the development and maintenance of normal thyroid function. ZBTB7A has been shown to promote the expression of genes that are involved in erythroid development and function, including those that produce thyroid hormones.

In addition to its role in erythroid development, ZBTB7A has also been shown to be involved in the regulation of cellular processes that are important for overall health. For example, ZBTB7A has been shown to play a role in the regulation of cell division and the cycle, as well as in the regulation of cell adhesion and migration.

The Potential as a Drug Target

The potential of ZBTB7A as a drug target is based on its involvement in the regulation of cellular processes that are important for overall health. ZBTB7A has been shown to promote the growth and survival of cancer cells, as well as to contribute to the development of various diseases, including cancer. As a result, ZBTB7A is a potential target for drugs that are designed to inhibit its activity or prevent its accumulation in cancer cells.

In addition to its potential as a drug target, ZBTB7A has also been shown to be a potential biomarker for various diseases. For example, ZBTB7A has been shown to be elevated in the blood of patients with certain types of cancer, as well as in the urine of patients with certain types of cancer. Additionally, ZBTB7A has been shown to be decreased in the blood of patients with certain types of cancer, as well as in the urine of patients with certain types of cancer. These findings suggest that ZBTB7A may be a useful biomarker for the diagnosis and treatment of various types of cancer.

The Potential as a Biomarker

The potential of ZBTB7A as a biomarker for various diseases is based on its expression in various tissues and its ability to be detected and measured. ZBTB7A has been shown to be expressed in a variety of tissues, including the blood, the spleen, the thymus, and the pancreas. As a result, ZBTB7A may be a useful biomarker for the diagnosis and treatment of various types of diseases.

In addition to its expression in various tissues, ZBTB7A has also been shown to be involved in the regulation of cellular processes that are important for overall health. For example, ZBTB7A has been shown to play a role in the regulation of cell division and the cycle, as well as in the regulation of cell adhesion and migration. These findings suggest that ZBTB7A may be a useful biomarker for the diagnosis and treatment of various types of diseases.

Conclusion

ZBTB7A is a protein that is expressed in the erythroid gland and is involved in the development and maintenance of normal thyroid function. ZBTB7A has also been shown to play a role in the regulation of cellular processes that are important for overall health, as well as in the development and progression of various diseases, including cancer. As a result, ZBTB7A has potential as a drug target or biomarker. Further research is needed to fully understand the role of ZBTB7A in these processes and its potential as a drug or biomarker.

Protein Name: Zinc Finger And BTB Domain Containing 7A

Functions: Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation (PubMed:14701838, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26455326, PubMed:26816381). Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions (PubMed:12004059, PubMed:17595526, PubMed:20812024, PubMed:25514493, PubMed:26816381). Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (PubMed:25514493). That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 (PubMed:25514493). Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA (PubMed:12004059). Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes (PubMed:20812024). Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Involved in the switch between fetal and adult globin expression during erythroid cells maturation (PubMed:26816381). Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription (PubMed:26816381). Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis (PubMed:26455326). Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation (PubMed:14701838). Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 (PubMed:24514149)

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