Zinc Finger Protein 12B: Potential Drug Target and Biomarker (G340554)

Target Name: ZC3H12B

NCBI ID: G340554

Zinc Finger Protein 12B: Potential Drug Target and Biomarker

Zinc finger CCCH domain-containing protein 12B (ZC3H12B) is a protein that is expressed in various tissues and organs in the human body. It is a member of the superfamily of CCCH-rich protein (CCCHP) and is characterized by the presence of a zinc finger domain and a CCCH-rich repeat. ZC3H12B has been shown to play a role in various cellular processes, including cell signaling, DNA replication, and chromatin remodeling.

One of the unique features of ZC3H12B is its ability to interact with other proteins and molecules. It has been shown to form a complex with various transcription factors, including RNA polymerase II (RNA-P2), nuclear factor of activating transcription (NFAT), and myristoylated alpha-tubulin (MyAT). These interactions allow ZC3H12B to influence the activity of these transcription factors and potentially play a role in gene expression.

In addition to its role in cell signaling, ZC3H12B has also been shown to be involved in the regulation of DNA replication. It has been shown to interact with the DNA replication machinery and may play a role in the regulation of the timing and order of DNA replication. This may be important for the development and progression of cancer, as changes in DNA replication patterns can contribute to the development of these diseases.

Another potential role for ZC3H12B is as a drug target. Its interaction with transcription factors and its role in cell signaling may make it an attractive target for small molecules that can modulate its activity. This is an area of ongoing research, and various studies have identified potential small molecules that can interact with ZC3H12B and influence its activity.

In addition to its potential as a drug target, ZC3H12B is also a potential biomarker. Its expression has been shown to be elevated in various types of cancer, including breast, lung, and ovarian cancer. This suggests that it may be a useful biomarker for the diagnosis and treatment of these diseases.

Overall, ZC3H12B is a complex protein that plays a role in various cellular processes, including cell signaling and DNA replication. Its interaction with transcription factors and its potential as a drug target and biomarker make it an interesting target for further research. Further studies are needed to fully understand its role in these processes and its potential as a drug.

Protein Name: Zinc Finger CCCH-type Containing 12B

Functions: May function as RNase and regulate the levels of target RNA species

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