ZBTB48: A Drug Target / Disease Biomarker (G3104)

Target Name: ZBTB48

NCBI ID: G3104

ZBTB48: A Drug Target / Disease Biomarker

ZBTB48 is a protein that is expressed in various tissues of the body, including the brain, heart, and liver. It is a member of the zinc finger gene family, which is a family of transcription factors that play a crucial role in the regulation of gene expression. ZBTB48 has been shown to be involved in a number of biological processes, including cell signaling, DNA replication, and stress response.

One of the most promising aspects of ZBTB48 is its potential as a drug target. Zinc finger genes have been shown to be involved in a wide range of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. In addition, ZBTB48 has been shown to be involved in a number of signaling pathways that are involved in the development and progression of these diseases.

One of the ways that ZBTB48 may be used as a drug target is its role in cell signaling. ZBTB48 has been shown to be involved in a number of signaling pathways that are involved in the development and progression of cancer. For example, studies have shown that ZBTB48 can promote the growth and survival of cancer cells, and that it can also inhibit the death of cancer cells that have been treated with certain chemotherapy drugs.

In addition to its role in cell signaling, ZBTB48 is also involved in the regulation of DNA replication. This is important because DNA replication is a critical process that is involved in the development and progression of cancer. ZBTB48 has been shown to be involved in the regulation of DNA replication in a number of ways. For example, studies have shown that ZBTB48 can cause cancer cells to enter a state of dormancy, which can help to prevent the development and progression of cancer.

Another potential way that ZBTB48 could be used as a drug target is its role in stress response. ZBTB48 has been shown to be involved in the regulation of stress response in a number of ways. For example, studies have shown that ZBTB48 can help to protect cells from the effects of stress, and that it can also help to regulate the release of stress hormones. These findings suggest that ZBTB48 may be a potential drug target for stress-related diseases.

Overall, ZBTB48 is a protein that is expressed in various tissues of the body, and it has been shown to be involved in a number of important biological processes. As a result, ZBTB48 may be a promising drug target for a wide range of diseases. Further research is needed to fully understand the role of ZBTB48 in these diseases, and to determine the most effective way to use it as a drug.

Protein Name: Zinc Finger And BTB Domain Containing 48

Functions: Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891)

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