Target Name: ITIH4
NCBI ID: G3700
Other Name(s): inter-alpha-inhibitor heavy chain 4 | Inter-alpha-trypsin inhibitor family heavy chain-related protein | inter-alpha-trypsin inhibitor heavy chain family member 4 | PK-120 | inter-alpha-trypsin inhibitor heavy chain 4 | 35 kDa inter-alpha-trypsin inhibitor heavy chain H4 | ITIH4 variant 2 | Inter-alpha-trypsin inhibitor, heavy chain-related protein | Inter-alpha-inhibitor heavy chain 4 | Inter-alpha-trypsin inhibitor heavy chain H4 | gp120 | ITIH4_HUMAN | ITIHL1 | inter-alpha-trypsin inhibitor family heavy chain-related protein | DKFZp686G21125 | OTTHUMP00000213834 | inter-alpha-trypsin inhibitor, heavy chain-like, 1 | inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein) | Inter-alpha-trypsin inhibitor heavy chain 4, transcript variant 2 | H4P | 70 kDa inter-alpha-trypsin inhibitor heavy chain H4 | Inter-alpha-trypsin inhibitor heavy chain H4 (isoform 1) | ITIH4 variant 1 | Plasma kallikrein sensitive glycoprotein 120 | Inter-alpha-trypsin inhibitor, heavy chain-like, 1 | OTTHUMP00000213869 | IHRP | Plasma kallikrein-sensitive glycoprotein 120 | Gp120 | GP120 | PK120 | Plasma kallikrein-sensitive glycoprotein | plasma kallikrein-sensitive glycoprotein 120 | OTTHUMP00000197121 | ITI heavy chain H4 | Inter-alpha-trypsin inhibitor heavy chain 4, transcript variant 1 | ITI-HC4 | Inter-alpha-trypsin inhibitor heavy chain H4 (isoform 2)

The Potential Use of ITIH4 as A Drug Target and Biomarker

ITIH4 (Inter-Alpha-Inhibitor Heavy Chain 4) is a protein that is expressed in various tissues and organs in the body. Its primary function is to regulate the activity of the alpha-helices, which are a type of protein that is found in many different proteins in the cell. There is a specific alpha-helical region of the protein that is known as the heavy chain, and ITIH4 is the name of the protein that is encoded by the heavy chain gene.

The alpha-helical region of proteins plays a crucial role in their function, as it allows them to interact with other proteins and perform a variety of different tasks. ITIH4 is a member of the family of ITIH proteins, which are known for their ability to inhibit the activity of the alpha-helices of other proteins. This protein has been shown to play a role in a variety of different processes in the cell, including the regulation of cell growth, the development of cancer, and the regulation of the immune system.

ITIH4 as a drug target

The potential use of ITIH4 as a drug target is one that has received a great deal of interest in recent years. This is because the alpha-helical region of proteins makes them difficult to target, as the constant movement of the alpha-helices makes it difficult for any molecules (molecules) to bind to them. However, researchers have identified several small molecules that have been shown to be able to interact with the alpha-helices of ITIH4 and are able to inhibit its activity.

One of the most promising ITIH4 drug targets is the molecule known as SM-301. This molecule is a small peptide that is able to bind to the alpha-helices of ITIH4 and inhibit its activity. Studies have shown that SM-301 is able to inhibit the growth of cancer cells, and may be a useful treatment for a variety of different types of cancer.

Another potential drug target for ITIH4 is the molecule known as IDH9. This molecule is a small protein that is expressed in the brain and has been shown to play a role in the regulation of the immune system. Studies have shown that IDH9 can interact with ITIH4 and may be able to inhibit its activity in this context.

ITIH4 as a biomarker

In addition to its potential use as a drug target, ITIH4 has also been shown to be a potential biomarker. This is because the alpha-helical region of proteins is often altered in the development of cancer, and changes in the alpha-helical region can be an indication of the presence of cancer. Studies have shown that ITIH4 levels are often elevated in a variety of different types of cancer, and may be a useful biomarker for the detection and treatment of these diseases.

In addition to its potential use as a drug target and biomarker, ITIH4 is also of interest to researchers because of its unique structure. The alpha-helices of ITIH4 are able to interact with a variety of different molecules, and the structure of these interactions is highly conserved across different species. This allows researchers to study the fundamental mechanisms of protein-protein interactions and the role of the alpha-helical region in this process.

Conclusion

ITIH4 is a protein that is of interest to researchers due to its unique structure and its ability to interact with other proteins. Its role in the regulation of the alpha-helical region of proteins makes it a potential drug target and a useful biomarker for the detection and treatment of a variety of different diseases. Further research is needed to fully understand the mechanisms of ITIH4 and its role in the cell.

Protein Name: Inter-alpha-trypsin Inhibitor Heavy Chain 4

Functions: Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration

More Common Targets

ITIH5 | ITIH6 | ITK | ITLN1 | ITLN2 | ITM2A | ITM2B | ITM2C | ITPA | ITPK1 | ITPK1-AS1 | ITPKA | ITPKB | ITPKB-IT1 | ITPKC | ITPR1 | ITPR1-DT | ITPR2 | ITPR3 | ITPRID1 | ITPRID2 | ITPRIP | ITPRIPL1 | ITPRIPL2 | ITSN1 | ITSN2 | IVD | IVL | IVNS1ABP | IWS1 | IYD | IZUMO1 | IZUMO1R | IZUMO2 | IZUMO4 | JADE1 | JADE2 | JADE3 | JAG1 | JAG2 | JAGN1 | JAK1 | JAK2 | JAK3 | JAKMIP1 | JAKMIP1-DT | JAKMIP2 | JAKMIP2-AS1 | JAKMIP3 | JAM2 | JAM3 | JAML | Janus Kinase | JARID2 | JAZF1 | JAZF1-AS1 | JCAD | JDP2 | JHY | JKAMP | JMJD1C | JMJD1C-AS1 | JMJD4 | JMJD6 | JMJD7 | JMJD7-PLA2G4B | JMJD8 | JMY | JOSD1 | JOSD2 | JPH1 | JPH2 | JPH3 | JPH4 | JPT1 | JPT2 | JPX | JRK | JRKL | JSRP1 | JTB | JUN | JUNB | JUND | JUP | K(ATP) Channel | KAAG1 | Kainate Receptor (GluR) | Kallikrein | KALRN | KANK1 | KANK2 | KANK3 | KANK4 | KANSL1 | KANSL1-AS1 | KANSL1L | KANSL2 | KANSL3 | KANTR