CDC136: A Potential Drug Target (G64753)

Target Name: CCDC136

NCBI ID: G64753

CDC136: A Potential Drug Target

CCDC136 (OTTHUMP00000212774) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the superfamily of cytoskeletal proteins, which are involved in the structure and function of cells. CCDC136 is unique because it is a transmembrane protein, meaning it spans the membrane of the cell. This allows it to interact with other proteins on the same or different membranes, making it a potential drug target.

The search for new drug targets is a constant in the world of medicine. Drug companies are always looking for new and innovative treatments that can address a wide range of diseases. One promising area of 鈥嬧?媟esearch is the study of protein targets, particularly those that are involved in signaling pathways that are important for human health. CCDC136 is one of these proteins that is being targeted for drug development.

CDC136 is a protein that is involved in several different signaling pathways. It is a key regulator of the TGF-β pathway, which is involved in the development and maintenance of tissues. The TGF-β pathway is a well-established regulator of many diseases , including cancer, cardiovascular disease, and neurodegenerative disorders. CCDC136 plays a critical role in the regulation of TGF-β activity by inhibiting the activity of the transcription factor SMAD.

In addition to its role in the TGF-β pathway, CCDC136 is also involved in the regulation of several other signaling pathways. It is a regulator of the PI3K/Akt pathway, which is involved in the regulation of cell survival and metabolism. It is also a regulator of the NF-kappa-B pathway, which is involved in the regulation of inflammation and immune responses.

The study of CCDC136 as a drug target is based on several different approaches. One of the primary ways to study it is through its expression levels. Researchers have used techniques such as qRT-PCR and western blotting to measure the levels of CCDC136 in different tissues and tissues. They have found that CCDC136 is highly expressed in a variety of tissues, including the brain, heart, and kidneys. This suggests that it may be a useful target for drugs that can modulate its expression levels.

Another way to study CCDC136 is through its function. Researchers have used a variety of techniques to determine the functions of CCDC136, including live cell imaging, biochemical assays, and cell-based assays. They have found that CCDC136 is involved in a wide range of cellular processes, including cell adhesion, migration, and invasion. This suggests that it may be a useful target for drugs that can modulate its functions.

Finally, researchers have also used computer-based models to predict the potential targets of CCDC136. This is a common approach used to identify potential drug targets based on the protein's known functions and the results of experiments such as qRT-PCR and western blotting. Using these models, researchers have identified several potential targets for CCDC136, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway.

In conclusion, CCDC136 is a protein that is involved in several different signaling pathways and is a potential drug target. Its high expression levels and complex functions in the TGF-β, PI3K/Akt, and NF-kappa-B pathways make it an attractive target for drugs that can modulate its expression or function. Further research is needed to determine the full potential of CCDC136 as a drug target and to develop safe and effective treatments for the diseases that are caused by its dysfunction.

Protein Name: Coiled-coil Domain Containing 136

Functions: May play a role in acrosome formation in spermatogenesis and in fertilization

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