Target Name: GPR157
NCBI ID: G80045
Other Name(s): G protein-coupled receptor 157 | FLJ12132 | GP157_HUMAN | G-protein coupled receptor 157 | probable G-protein coupled receptor 157 | G Protein-Coupled Receptor 157 (GPR157)

GPR157: A GPCR Involved in Pain Perception, Neurotransmission and Hormone Signaling

G protein-coupled receptors (GPCRs) are a family of transmembrane proteins that play a crucial role in cellular signaling. GPCRs are involved in various physiological processes, including sensory perception, neurotransmission, and hormone signaling. GPR157 is a GPCR that is expressed in various tissues and is involved in pain perception, neurotransmission, and hormone signaling.

GPR157 is a 150- amino acid protein that consists of an extracellular domain, a transmembrane region, and an intracellular domain. The extracellular domain of GPR157 contains a N-terminus that is involved in protein-protein interactions and is known as the G protein-coupled receptor 157 (GPCR157) dimerization domain. The transmembrane region of GPR157 contains a unique triderminal pattern that is composed of a highly conserved N-terminus, a transmembrane segment, and a C-terminus. The intracellular domain of GPR157 contains a unique farnesylation site and a tyrosine phosphorylation site.

GPR157 is involved in pain perception and neurotransmission. GPR157 is known to play a crucial role in the sense of pain. GPR157 is expressed in various tissues, including brain, muscle, pancreas, and reproductive organs. Studies have shown that GPR157 is involved in pain perception and neurotransmission. For instance, GPR157 has been shown to be involved in the modulation of pain transmission in neuro-injured rats.

GPR157 is also involved in neurotransmission. GPR157 is known to play a role in neurotransmission in various tissues. For instance, GPR157 has been shown to be involved in the modulation of neurotransmission in the hypothalamus, a region of the brain that is involved in regulating various physiological processes. GPR157 has been shown to interact with various neurotransmitter systems, including GABA, serotonin, and dopamine.

GPR157 is also involved in hormone signaling. GPR157 has been shown to play a role in hormone signaling in various tissues. For instance, GPR157 has been shown to be involved in the modulation of insulin signaling in pancreatic beta cells. GPR157 has also been shown to play a role in the modulation of testosterone signaling in prostate tissue.

GPR157 is a potential drug target. GPR157 is a unique GPCR that is involved in various physiological processes, including pain perception, neurotransmission, and hormone signaling. Therefore, GPR157 is a potential drug target. Researchers are currently working to develop small molecules that can selectively target GPR157 and modulate its activity.

In conclusion, G protein-coupled receptor 157 (GPCR157) is a GPCR that is involved in various physiological processes, including pain perception, neurotransmission, and hormone signaling. GPR157 is a potential drug target due to its unique structure and its involvement in various physiological processes. Further research is needed to understand the full role of GPR157 and to develop small molecules that can selectively target GPR157 and modulate its activity.

Protein Name: G Protein-coupled Receptor 157

Functions: Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger

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GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4 | GPR42 | GPR45 | GPR50 | GPR52 | GPR55 | GPR6 | GPR61 | GPR62 | GPR63 | GPR65 | GPR68 | GPR75 | GPR75-ASB3 | GPR78 | GPR79 | GPR82 | GPR83 | GPR84 | GPR84-AS1 | GPR85 | GPR87 | GPR88 | GPR89A | GPR89B | GPRACR | GPRASP1 | GPRASP2 | GPRASP3 | GPRC5A | GPRC5B | GPRC5C | GPRC5D | GPRC5D-AS1 | GPRC6A | GPRIN1 | GPRIN2 | GPRIN3 | GPS, PLAT and transmembrane domain-containing protein | GPS1 | GPS2 | GPS2P1 | GPSM1 | GPSM2 | GPSM3 | GPT | GPT2 | GPX1 | GPX1P1 | GPX2 | GPX3 | GPX4 | GPX5 | GPX6 | GPX7 | GPX8 | GRAMD1A | GRAMD1B | GRAMD1C | GRAMD2A | GRAMD2B | GRAMD4 | GRAMD4P2 | GRAMD4P5 | GRAMD4P7 | Granzyme | GRAP