Target Name: GPR137C
NCBI ID: G283554
Other Name(s): G protein-coupled receptor 137C, transcript variant 2 | TM7SF1L2 | GPR137C variant 2 | G137C_HUMAN | Transmembrane 7 superfamily member 1-like 2 protein | Integral membrane protein GPR137C | G protein-coupled receptor 137C | Integral membrane protein GPR137C (isoform 2) | transmembrane 7 superfamily member 1-like 2 protein | G protein-coupled receptor TM7SF1L2

Study on GPCR137C: Drug Target and Potential Biomarker for Diseases

G Protein-Coupled Receptor 137C (GPCR137C) is a G protein-coupled receptor that is expressed in many tissues throughout the body. It is a member of the GPCR family, which is a large family of transmembrane proteins that play an important role in cellular signaling. GPCR137C is one of the many GPCR genes that have been identified and studied, and it is currently a drug target and a potential biomarker for a variety of diseases.

GPCR137C is a 14 kDa protein that is expressed in the brain, heart, liver, and other tissues. It is highly conserved between species, with a calculated pI of 12.93. GPCR137C has four transmembrane domains: an N-terminus, a T-terminus , a middle alpha-helix, and a C-terminus. The N-terminus is the most well-studied, and it contains a putative extracellular loop (ECL) that is involved in GPCR137C function. The T-terminus is also well-studied , and it contains a protein-coding region that is involved in GPCR signaling. The middle alpha-helix is 鈥嬧?媋 transmembrane domain that is known for its role in GPCR signaling, and the C-terminus is the least well-studied.

GPCR137C is a G protein-coupled receptor, which means that it is a protein that is targeted by the neurotransmitter GABA. GPCR137C is involved in a variety of physiological processes, including sensory perception, motor function, and regulation of inflammation. It is also involved in diseases such as Alzheimer's disease, Parkinson's disease, and neurodegenerative disorders.

GPCR137C has been identified as a potential drug target by researchers because of its role in a variety of diseases. For example, GPCR137C has been shown to be involved in the development and progression of Alzheimer's disease. Studies have shown that individuals with the GPCR137C genetic variant have an increased risk of developing Alzheimer's disease, and that inhibiting GPCR137C activity may be a potential treatment for this disease.

GPCR137C has also been shown to be involved in the regulation of pain. Studies have shown that GPCR137C is involved in the regulation of pain perception, and that inhibiting GPCR137C activity may be a potential treatment for chronic pain.

In addition to its potential as a drug target, GPCR137C is also a potential biomarker for a variety of diseases. For example, GPCR137C has been shown to be involved in the regulation of inflammation, and that inhibiting GPCR137C activity may be a potential treatment for autoimmune diseases.

GPCR137C is also a potential target for small molecules because of its unique structure. The N-terminus of GPCR137C contains a putative ECL that is involved in GPCR signaling. This ECL is a potential binding site for small molecules, and researchers are currently exploring the potential of small molecules as a treatment for GPCR137C-related diseases.

In conclusion, G Protein-Coupled Receptor 137C (GPCR137C) is a G protein-coupled receptor that is involved in a variety of physiological processes and is a potential drug target and biomarker for a variety of diseases. The unique structure of GPCR137C, including its putative ECL, makes it an attractive target for small molecules, and its role in sensory perception, motor function, and regulation of inflammation makes it a promising candidate for a variety of treatments. Further research is needed to fully understand the function of GPCR137C and its potential as a drug

Protein Name: G Protein-coupled Receptor 137C

Functions: Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes

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