ITGB4: A Versatile Tool for Drug Targets and Biomarkers (G3691)

Target Name: ITGB4

NCBI ID: G3691

ITGB4: A Versatile Tool for Drug Targets and Biomarkers

ITGB4 (Integrated Tissue Gene Expression Database 4) is a database that was developed to study gene expression in various organisms. It is a comprehensive resource that allows researchers to identify and analyze gene expression patterns in a given organism. In this article, we will discuss ITGB4 as a drug target and its potential as a biomarker.

ITGB4 is a repository of gene expression data that was generated using a variety of techniques, including RNA sequencing and microarray analysis. It contains information on gene expression in various organisms, including plants, animals, and fungi. This database can be used to identify differentially expressed genes in an organism, which can be useful for identifying potential drug targets.

One of the key features of ITGB4 is its ability to identify gene expression patterns invarious organisms. This makes it an attractive tool for identifying potential drug targets. For example, ITGB4 can be used to identify potential drug targets in cancer cells. By analyzing gene expression patterns in cancer cells, researchers can identify differentially expressed genes that are involved in cancer development. This can lead to the development of new treatments for cancer.

Another potential use of ITGB4 is as a biomarker. ITGB4 contains information on gene expression in various organisms, which can be used to identify biomarkers for disease. For example, ITGB4 can be used to identify genes that are involved in aging and age-related diseases. This information can be used to develop new treatments for aging and age-related diseases.

ITGB4 has also been used to study gene expression in diseases such as diabetes and neurodegenerative diseases. By analyzing gene expression patterns in these diseases, researchers have identified potential drug targets that could lead to new treatments.

In conclusion, ITGB4 is a valuable tool for identifying potential drug targets and biomarkers. Its ability to identify gene expression patterns in various organisms makes it an attractive resource for researchers studying gene expression and disease. Further research can be conducted to determine the full potential of ITGB4 as a drug target and biomarker.

Protein Name: Integrin Subunit Beta 4

Functions: Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464)

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