CDC134: A Protein Regulator of Cell Proliferation and Adhesion

Target Name: CCDC134

NCBI ID: G79879

CDC134: A Protein Regulator of Cell Proliferation and Adhesion

CCDC134 (FLJ22349) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the flj family, which is characterized by the presence of a characteristic flj domain and a distinct N- terminus. CCDC134 is also known as CDK4, and it plays a role in the regulation of cell proliferation and differentiation.

CDC134 is a transcription factor that is involved in the development and maintenance of neural stem cells. It is a key regulator of the PDX1 gene, which is responsible for the production of the protein PDX1. PDX1 is a potent negative regulator of cell proliferation, and it is thought to play a role in the development and maintenance of cancer.

CDC134 is also involved in the regulation of cell adhesion. It is a positive regulator of the tight-cell adhesion molecule (TCAM), which is involved in the formation of tight junctions between adjacent cells. tight junctions are critical for the proper functioning of tissues , including the brain, and they are thought to be involved in the development and progression of various diseases, including cancer.

In addition to its role in cell proliferation and adhesion, CDC134 is also involved in the regulation of cell survival. It is a negative regulator of the p53 gene, which is responsible for the production of the protein p53. p53 is a critical regulator of DNA repair and cell survival, and it is thought to play a key role in the regulation of cancer development.

CDC134 is also involved in the regulation of cell migration. It is a positive regulator of the migration protein molecule (Magellan), which is involved in the proper functioning of cells. Magellan helps cells undergo mitosis, thus ensuring the generation of new cells.

CDC134 is also involved in the regulation of cell signaling pathways. It is a positive regulator of the protein kinase A1 (PKA1), which is involved in the regulation of many cellular processes, including cell signaling pathways.

CDC134 is a protein that is expressed in various tissues of the body, and it plays a critical role in the regulation of cell proliferation, adhesion, survival, and signaling pathways. It is also a potential drug target and biomarker for various diseases, including cancer . Further research is needed to fully understand the role of CDC134 in the regulation of cellular processes and its potential as a drug.

Protein Name: Coiled-coil Domain Containing 134

Functions: In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808). Has a critical role in the regulation of osteogenesis and bone development (PubMed:32181939)

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