ITGAX: A Potential Drug Target for Cancer, Neurodegenerative Diseases and Cardiovascular Disease

Target Name: ITGAX

NCBI ID: G3687

ITGAX: A Potential Drug Target for Cancer, Neurodegenerative Diseases and Cardiovascular Disease

ITGAX, also known as Leu M5 and alpha subunit, is a protein that is expressed in various tissues of the body, including the brain, heart, and blood vessels. It is a member of the ITGAX family, which is characterized by the presence of the extracellular domain alpha-helical structure.

The alpha subunit of ITGAX is a 21-kDa protein that is expressed in the brain, heart, and blood vessels. It is involved in the regulation of cell adhesion, migration, and survival. The alpha subunit is a key component of the cadherin complex , which is a transmembrane protein that plays a central role in cell-cell adhesion.

Recent studies have suggested that ITGAX may be a drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

One of the reasons for the interest in ITGAX is its potential role in cancer. Many studies have shown that ITGAX is highly expressed in various types of cancer, including breast, lung, and ovarian cancer. Additionally, these studies have suggested that ITGAX may be involved in the development and progression of cancer. For example, one study found that women with breast cancer were more likely to have higher levels of ITGAX than those without the disease.

Another potential application of ITGAX is its role in neurodegenerative diseases. Many of these diseases, such as Alzheimer's disease and Parkinson's disease, are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles. ITGAX has been shown to be involved in the regulation of neurofibrillary tangles and may be a potential target for the development of neurodegenerative drugs.

ITGAX has also been shown to be involved in cardiovascular disease. Many studies have suggested that ITGAX may be involved in the regulation of cardiovascular function and may be a potential target for the development of cardiovascular drugs. For example, one study found that individuals with heart failure had lower levels of ITGAX than those without the condition.

In conclusion, ITGAX is a protein that is expressed in various tissues of the body and is involved in the regulation of cell adhesion, migration, and survival. The alpha subunit of ITGAX is a 21-kDa protein that is a key component of the cadherin complex and has been shown to be involved in the regulation of various physiological processes, including cancer, neurodegenerative diseases, and cardiovascular disease. As a result, ITGAX may be a potential drug target or biomarker for these diseases and has the potential to be a valuable tool in the development of new therapies.

Protein Name: Integrin Subunit Alpha X

Functions: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis

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