Target Name: GPR137B
NCBI ID: G7107
Other Name(s): Integral membrane protein GPR137B | transmembrane 7 superfamily member 1 protein | Transmembrane 7 superfamily member 1 protein | Transmembrane 7 superfamily member 1 (upregulated in kidney) | G137B_HUMAN | transmembrane 7 superfamily member 1 (upregulated in kidney) | G protein-coupled receptor 137B | OTTHUMP00000036107 | TM7SF1 | OTTHUMP00000036106

GPR137B: A Potential Drug Target and Biomarker for Neurodegenerative Disorders

G protein-coupled receptors (GPCRs) are a family of transmembrane proteins that play a crucial role in cellular signaling. GPCRs are involved in various physiological processes, including sensory perception, neurotransmission, and hormone signaling. The GPCR family consists of 70 subfamilies, with GPR137B being one of them. GPR137B is a type of GPCR that is expressed in many tissues and cells, including the brain.

GPR137B is a 19-kDa integral membrane protein that is characterized by its transmembrane and intracellular localization. It consists of an extracellular loop, a transmembrane segment, and an intracellular loop. The extracellular loop is responsible for the protein's targeting to the endoplasmic reticulum (ER) and for its subsequent release. The transmembrane segment is responsible for the protein's interaction with intracellular signaling molecules. The intracellular loop is responsible for the protein's interaction with GPCR-coupled receptors.

GPR137B is involved in various physiological processes, including neurotransmission and hormone signaling. It is a negative regulator of the neurotransmitter action potential (AP) in the postsynaptic terminal of neurons. GPR137B interacts with the neurotransmitter acetylcholine (ACh) to inhibit the release of neurotransmitters. This interaction between GPR137B and ACh is a critical mechanism that regulates synaptic plasticity and learning.

In addition to its role in neurotransmission, GPR137B is also involved in the regulation of hormone signaling. It is a negative regulator of the androgen receptor (AR), which is responsible for the regulation of male sexual function and prostate growth. GPR137B interacts with the hormone testosterone (T) to inhibit its effects on AR. This interaction between GPR137B and T is a critical mechanism that regulates male sexual function and prostate growth.

GPR137B is also involved in the regulation of inflammation. It is a negative regulator of the nuclear factor kappa B (NFkB), which is a transcription factor that regulates inflammation. GPR137B interacts with the protein Bad (BAI1) to inhibit its effects on NFkB. This interaction between GPR137B and Bad is a critical mechanism that regulates inflammation and immune responses.

GPR137B is a potential drug target for various neurodegenerative disorders. Its involvement in the regulation of neurotransmission, hormone signaling, and inflammation makes it an attractive target for therapeutic intervention.

One of the potential therapeutic strategies for GPR137B is the inhibition of its activity. The inhibition of GPR137B activity can be achieved through various methods, including small molecule inhibitors, genetic modifiers, and biochemical assays. For example, a small molecule inhibitor, such as a peptide or a protein fragment, can be designed to bind to GPR137B and prevent it from interacting with intracellular signaling molecules. Genetic modifiers, such as RNA interference or CRISPR/Cas9, can also be used to modify GPR137B expression levels. Biochemical assays, such as immunofluorescence or Western blotting, can be used to measure the levels of GPR137B in cells or tissues and to monitor its effects on cellular signaling processes.

In conclusion, GPR137B is a potential drug target and biomarker for neurodegenerative disorders. Its involvement in the regulation of neurotransmission, hormone signaling, and inflammation makes it an attractive target for therapeutic intervention. The inhibition of GPR137B

Protein Name: G Protein-coupled Receptor 137B

Functions: Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939)

More Common Targets

GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4 | GPR42 | GPR45 | GPR50 | GPR52 | GPR55 | GPR6 | GPR61 | GPR62 | GPR63 | GPR65 | GPR68 | GPR75 | GPR75-ASB3 | GPR78 | GPR79 | GPR82 | GPR83 | GPR84 | GPR84-AS1 | GPR85 | GPR87 | GPR88 | GPR89A | GPR89B | GPRACR | GPRASP1 | GPRASP2 | GPRASP3 | GPRC5A | GPRC5B | GPRC5C | GPRC5D | GPRC5D-AS1 | GPRC6A | GPRIN1 | GPRIN2 | GPRIN3 | GPS, PLAT and transmembrane domain-containing protein | GPS1 | GPS2 | GPS2P1 | GPSM1 | GPSM2 | GPSM3 | GPT | GPT2 | GPX1 | GPX1P1 | GPX2 | GPX3