Target Name: GPR108
NCBI ID: G56927
Other Name(s): GP108_HUMAN | Lung seven transmembrane receptor 2 | G Protein-Coupled Receptor 108 | Protein GPR108 | Protein GPR108 (isoform 1) | G protein-coupled receptor 108, transcript variant 1 | GPR108 variant 1 | lung seven transmembrane receptor 2 | G protein-coupled receptor 108 | LUSTR2

GPR108: A Potential Drug Target for Psychiatric Disorders and Cancer

GPR108 (GP108_HUMAN) is a gene that has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. GPR108 is a member of the G-protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a key role in cellular signaling.

GPR108 is expressed in various tissues and cells in the body, including the brain, nervous system, and endothelial cells. It is known to be involved in the regulation of cellular processes that are important for brain development, function, and survival, including neuronal signaling, neurotransmitter release, and cell survival.

Studies have suggested that GPR108 may be involved in the development and progression of various psychiatric disorders, including depression, anxiety, and schizophrenia. For example, GPR108 has been shown to be expressed in the brains of individuals with major depressive disorder (MDD) and has been involved in the regulation of neurotransmitter release in these individuals.

In addition to its potential role in psychiatric disorders, GPR108 has also been suggested as a potential drug target for cancer. For example, GPR108 has been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels form in tumors. This may make it a useful target for cancer treatments that target angiogenesis.

GPR108 has also been shown to be involved in the regulation of pain perception and neuroinflammation, which are important factors in the development and progression of chronic pain and neuroinflammatory diseases.

In conclusion, GPR108 is a promising drug target or biomarker for a variety of psychiatric and neurological disorders. Further research is needed to fully understand its role in these conditions and to develop effective treatments.

Protein Name: G Protein-coupled Receptor 108

Functions: May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response

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GPR119 | GPR12 | GPR132 | GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4 | GPR42 | GPR45 | GPR50 | GPR52 | GPR55 | GPR6 | GPR61 | GPR62 | GPR63 | GPR65 | GPR68 | GPR75 | GPR75-ASB3 | GPR78 | GPR79 | GPR82 | GPR83 | GPR84 | GPR84-AS1 | GPR85 | GPR87 | GPR88 | GPR89A | GPR89B | GPRACR | GPRASP1 | GPRASP2 | GPRASP3 | GPRC5A | GPRC5B | GPRC5C | GPRC5D | GPRC5D-AS1 | GPRC6A | GPRIN1 | GPRIN2 | GPRIN3 | GPS, PLAT and transmembrane domain-containing protein | GPS1 | GPS2 | GPS2P1 | GPSM1 | GPSM2 | GPSM3