GOLGA4: A Protein Involved in Various Diseases and Drug Targets

Target Name: GOLGA4

NCBI ID: G2803

GOLGA4: A Protein Involved in Various Diseases and Drug Targets

GOLGA4 (OTTHUMP00000208897) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the GOLGA family, which is characterized by the presence of a unique transmembrane domain and a characteristic pattern of localization of the protein in the cytoplasm. GOLGA4 is unique among its family members because of its ability to form aggregates in the cytoplasm, which are thought to play a role in the regulation of cellular processes such as signaling and intracellular transport.

GOLGA4 is also of interest because it is a potential drug target. Several studies have suggested that GOLGA4 may be involved in a variety of cellular processes that are relevant to the development and treatment of various diseases, including neurodegenerative disorders, cardiovascular disease, and kidney disease . In addition, GOLGA4 has also been shown to be a potential biomarker for several diseases, including cancer.

One of the key features of GOLGA4 is its ability to form aggregates in the cytoplasm. These aggregates, which are composed of multiple copies of the protein, are typically formed when GOLGA4 is expressed in cells and are characterized by the presence of a characteristic \" diffuse\" pattern in the cytoplasm. This pattern is thought to be caused by the aggregates' ability to move and diffuse throughout the cytoplasm, allowing them to interact with other cellular structures and components.

GOLGA4 has been shown to play a role in several cellular processes that are relevant to the development and treatment of various diseases. For example, several studies have suggested that GOLGA4 may be involved in the regulation of intracellular signaling pathways, such as the TGF-β pathway. This pathway is involved in the regulation of cellular processes such as cell growth, differentiation, and signaling, and is thought to be involved in the development and progression of many diseases, including cancer.

In addition to its role in intracellular signaling, GOLGA4 is also thought to be involved in the regulation of cellular transport processes. Several studies have shown that GOLGA4 is involved in the transport of various proteins to the endoplasmic reticulum, a structure that is responsible for the delivery of proteins to the cell surface. This function is thought to be important for the regulation of cellular processes such as signaling and metabolism.

GOLGA4 has also been shown to be involved in the regulation of cellular stress responses. When cells are exposed to stressors, such as toxins or radiation, GOLGA4 is often involved in the regulation of cellular stress responses, including the production of reactive oxygen species (ROS ) and the activation of cellular signaling pathways that are involved in stress response. This function is important for the regulation of cellular processes that are critical for the survival of the cell in response to stress.

In addition to its role in cellular signaling and transport processes, GOLGA4 is also thought to be involved in the regulation of cytoskeletal structure and dynamics. Several studies have shown that GOLGA4 is involved in the regulation of cytoskeletal filament dynamics, which are thought to play a role in the regulation of cell shape and movement. This function is important for the regulation of cellular processes such as cell migration and the development of cancer.

GOLGA4 is also of interest as a potential drug target because of its role in the regulation of cellular processes that are involved in the development and progression of various diseases. For example, several studies have suggested that GOLGA4 may be involved in the regulation of neurodegenerative disorders , such as Alzheimer's disease and Parkinson's disease. In addition, GOLGA4 has also been shown to be involved in the regulation of cardiovascular disease,

Protein Name: Golgin A4

Functions: Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197)

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