GPBP1L1: A Potential Drug Target for Cancer and Neurodegenerative Diseases

GPBP1L1: A Potential Drug Target for Cancer and Neurodegenerative Diseases

Gene expression is regulated by a complex interplay of genetic and epigenetic factors. One of the key factors influencing gene expression is the DNA-protein interactions, where transcription factors (TFs) bind to specific DNA regions to regulate gene expression. The study of these interactions has led to the identification of numerous gene-protein interactions (GPPPs) and their role in cancer, neurodegenerative diseases, and other diseases.

One of the well-established GPPPs is the GC-rich promoter-binding protein 1-like 1 (GPBP1L1), which is a protein that binds to the GC-rich promoter of target genes. GPBP1L1 is a member of the GPPB family, which includes several similar proteins that share a conserved catalytic core and a N-terminal transmembrane domain. GPBP1L1 has been shown to play a role in various cellular processes, including cell signaling, DNA replication, and metabolism.

Currently, several drugs are being targeting developed GPPB1L1 and its associated diseases. In this article, we will provide an overview of GPBP1L1, its functions, and potential as a drug target.

FUNCTION OF GPBP1L1

GPBP1L1 is a 22 kDa protein that is expressed in various cell types, including neurons, muscle cells, and red blood cells. It is primarily localized to the endoplasmic reticulum (ER) and nuclear envelope (NE), where it can interact with various nuclear proteins, including nuclear factor of activating transcription (NFAT) and p53.

GPBP1L1 functions as a protein kinase-activating protein (PkAP), which means that it can interact with protein kinases and activate them. This interaction between GPBP1L1 and protein kinases is critical for various cellular processes, including cell signaling, DNA replication, and metabolism.

GPBP1L1 has been shown to play a role in cell signaling by regulating the activity of several protein kinases, including casein kinase (CK) and heat shock protein 70 (Hsp70). For example, GPBP1L1 has been shown to interact with CK and activate its activity , which is involved in cell signaling, protein synthesis, and DNA replication.

GPBP1L1 has also been shown to play a role in DNA replication by regulating the activity of the DNA-protein complex. In DNA replication, GPBP1L1 is thought to function as a cofactor of the DNA-protein complex, which is responsible for the initiation of replication and the regulation of the replication process.

In addition to its role in cell signaling and DNA replication, GPBP1L1 has also been shown to play a role in metabolism. For example, GPBP1L1 has been shown to regulate the activity of the enzyme, which is involved in the metabolism of amino acids and glucose.

POTENTIAL AS A DRUG TARGET

The identification of GPPB1L1 as a potential drug target has led to the development of several small molecules that can inhibit its activity. These small molecules have been shown to have a variety of effects on cellular processes, including the regulation of cell signaling, DNA replication, and metabolism.

One of the most promising small molecules for targeting GPBP1L1 is the PI3K inhibitor N-[3-(4-fluorobutyl)-5-isothiocyanate](N-FIC)2, which has been shown to inhibit the activity of GPBP1L1 and its downstream targets . N-FIC2 has been shown to inhibit the activation of casein kinase (CK) and Hsp70, which are known to be interacting with GPBP1L1.

Another small molecule that has been shown to inhibit GPBP1L1 is the DNA-binding protein p15, which has been shown to interact with GPBP1L1 and inhibit its activity. p15 is a

Protein Name: GC-rich Promoter Binding Protein 1 Like 1

Functions: Possible transcription factor

More Common Targets

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