Target Name: GPI
NCBI ID: G2821
Other Name(s): autocrine motility factor | Autocrine motility factor | GPI variant 2 | Glucose-6-phosphate isomerase (isoform 4) | D-glucose-6-phosphate ketol-isomerase | Glucose-6-phosphate isomerase | Hexosephosphate isomerase | NLK | oxoisomerase | Glucose-6-phosphate isomerase (isoform 2) | Sperm antigen-36 | Glucose-6-phosphate isomerase (isoform 1) | phosphohexose isomerase | Hexose monophosphate isomerase | phosphosaccharomutase | Glucose-6-phosphate isomerase, transcript variant 4 | phosphoglucose isomerase | sperm antigen-36 | GNPI | hexosephosphate isomerase | Neuroleukin | Phosphohexose isomerase | neuroleukin | Oxoisomerase | G6PI_HUMAN | Glucose phosphate isomerase | PGI | PHI | hexose monophosphate isomerase | SA36 | phosphohexomutase | SA-36 | AMF | GPI variant 4 | Phosphoglucose isomerase | Phosphohexomutase | Glucose-6-phosphate isomerase, transcript variant 2 | glucose-6-phosphate isomerase | Sperm antigen 36 | Glucose-6-phosphate isomerase, transcript variant 1 | GPI variant 1 | Phosphosaccharomutase

GPI: A Protein Involved in Various Bodily Processes and Disease Development

GPI (autocrine motility factor) is a protein that is expressed in various tissues throughout the body, including the brain, heart, kidneys, and intestines. It is a key regulator of cell movement and plays a role in the development and maintenance of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

GPI is a transmembrane protein that consists of a catalytic domain, a transmembrane region, and an extracellular domain. The catalytic domain is responsible for the protein's catalytic activity, while the transmembrane region is responsible for its stability and functions as an intracellular signaling molecule. The extracellular domain is involved in GPI's interactions with other proteins and factors in the extracellular environment.

GPI is involved in many different processes in the body, including the regulation of cell division, the establishment of cell-cell adhesion, and the regulation of ion and solute transport. It is also involved in the development and maintenance of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the most promising applications of GPI as a drug target is its role in cancer. GPI has been shown to play a role in the regulation of cell division and has been implicated in the development and progression of various types of cancer. For example, studies have shown that high levels of GPI are associated with poor prognosis in cancer patients and that inhibiting GPI signaling may be a promising therapeutic approach for cancer treatment.

Another promising application of GPI is its role as a biomarker for neurodegenerative diseases. GPI has been shown to be involved in the development and progression of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Therefore, GPI may be a useful biomarker for these disorders and may help to identify potential therapeutic approaches.

GPI is also involved in the regulation of ion and solute transport, which is important for maintaining the proper functioning of various physiological processes in the body. Imbalances in ion and solute transport can lead to a range of disorders, including hypoosmolality (low serum sodium levels), hyperoosmolality (high serum sodium levels), and the development of certain cancers. Therefore, GPI may be involved in the regulation of ion and solute transport and may be a useful target for the development of new treatments for a range of disorders.

In conclusion, GPI is a protein that is involved in a wide range of physiological processes in the body and has been implicated in the development and progression of various diseases. As a result, GPI is a promising target for the development of new drugs and therapies. Further research is needed to fully understand the role of GPI in these processes and to develop effective treatments for the disorders associated with its dysfunction.

Protein Name: Glucose-6-phosphate Isomerase

Functions: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:28803808). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (PubMed:11437381). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:3352745, PubMed:11004567). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:3352745, PubMed:11004567)

More Common Targets

GPI transamidase complex | GPI-GlcNAc transferase complex | GPIHBP1 | GPKOW | GPLD1 | GPM6A | GPM6B | GPN1 | GPN2 | GPN3 | GPNMB | GPR101 | GPR107 | GPR108 | GPR119 | GPR12 | GPR132 | GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4 | GPR42 | GPR45 | GPR50 | GPR52 | GPR55 | GPR6 | GPR61 | GPR62 | GPR63 | GPR65 | GPR68 | GPR75 | GPR75-ASB3 | GPR78 | GPR79 | GPR82 | GPR83 | GPR84 | GPR84-AS1 | GPR85 | GPR87 | GPR88 | GPR89A | GPR89B | GPRACR | GPRASP1 | GPRASP2 | GPRASP3 | GPRC5A | GPRC5B