Target Name: GPNMB
NCBI ID: G10457
Other Name(s): glycoprotein nmb-like protein | HGFIN | NMB | Transmembrane glycoprotein NMB (isoform b) | Transmembrane glycoprotein HGFIN | Glycoprotein nmb, transcript variant 2 | Transmembrane glycoprotein NMB (isoform a) | Glycoprotein nmb-like protein | GPNMB variant 1 | PLCA3 | Glycoprotein NMB | hematopoietic growth factor inducible neurokinin-1 type | Osteoactivin | glycoprotein nonmetastatic melanoma protein B | Transmembrane glycoprotein NMB | glycoprotein nmb | transmembrane glycoprotein HGFIN | glycoprotein (transmembrane) nmb | OTTHUMP00000122417 | Glycoprotein nmb, transcript variant 1 | Transmembrane glycoprotein | GPNMB variant 2 | Glycoprotein (transmembrane) nmb | Hematopoietic growth factor inducible neurokinin-1 type | GPNMB_HUMAN | osteoactivin | OTTHUMP00000202127

GPNMB: A protein involved in cell signaling and disease

Glycoprotein NMB-like protein (GPNMB) is a protein that is expressed in various tissues throughout the body. It is a type of transmembrane protein that is composed of a cytoplasmic tail and a transmembrane region that contains a N-terminus and a C-terminus. GPNMB is also known as nanobulin protein 2 (NBP2) or glycoprotein NMB-like protein 2 (GPNMB-2).

GPNMB is a protein that is expressed in various tissues throughout the body, including the brain, heart, liver, and kidneys. It is a type of transmembrane protein that is composed of a cytoplasmic tail and a transmembrane region that contains a N-terminus and a C-terminus. The N-terminus of GPNMB contains a glycine-rich region that is involved in the formation of the protein's N-glycosylation. The C-terminus of GPNMB contains a variable region that is involved in the protein's stability and localization to the cell surface.

GPNMB is involved in various cellular processes that are important for cell survival and function. For example, GPNMB is involved in the regulation of cell adhesion, as it is a member of the cadherin family of transmembrane proteins. In addition, GPNMB is involved in the regulation of cell signaling pathways, as it is a target for several different signaling pathways.

GPNMB is also a potential drug target for several diseases. For example, GPNMB has been shown to be involved in the development and progression of several types of cancer, including breast cancer, lung cancer, and liver cancer. In addition, GPNMB has been shown to be involved in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

GPNMB is also a potential biomarker for several diseases. For example, GPNMB has been shown to be involved in the diagnosis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In addition, GPNMB has been shown to be involved in the diagnosis of certain types of cancer, such as breast cancer and lung cancer.

In conclusion, GPNMB is a protein that is expressed in various tissues throughout the body and is involved in various cellular processes that are important for cell survival and function. It is also a potential drug target and biomarker for several diseases. Further research is needed to fully understand the role of GPNMB in these processes and to develop effective treatments for these diseases.

Protein Name: Glycoprotein Nmb

Functions: Could be a melanogenic enzyme

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