Target Name: GOSR1
NCBI ID: G9527
Other Name(s): P28 | Golgi SNAP receptor complex member 1 (isoform 1) | Golgi SNAP receptor complex member 1, transcript variant 1 | Golgi SNAP receptor complex member 1 | cis-golgi SNARE | GS28 | Cis-golgi SNARE | GOLIM2 | GOSR1_HUMAN | GOS-28 | GOS28/P28 | Golgi SNARE 28 kDa | Golgi integral membrane protein 2 | GOS28 | 28 kDa Golgi SNARE protein | 28 kDa cis-Golgi SNARE p28 | golgi SNAP receptor complex member 1 | GOSR1 variant 1 | golgi integral membrane protein 2

GOSR1: A Potential Drug Target for Muscle-Related Conditions

GOSR1 (Glycophosphorylase 1) is a protein that is expressed in various tissues throughout the body, including skeletal muscles, heart, and brain. It is a member of the G protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a crucial role in cellular signaling. GOSR1 is characterized by its unique catalytic mechanism, which involves the phosphorylation of a specific amino acid residue on the protein.

The research on GOSR1 has primarily focused on its role in muscle physiology and metabolism. GOSR1 is involved in the regulation of muscle protein synthesis and degradation, as well as muscle force production. It has been shown to play a critical role in the regulation of muscle growth and maintenance, and is often targeted by drugs that are used to treat muscle-related conditions, such as muscle dystrophy and myopathies.

In addition to its role in muscle physiology, GOSR1 has also been shown to be involved in several other physiological processes in the body. For example, it has been shown to play a role in the regulation of ion channels, which are responsible for the flow of electrical current through cells. GOSR1 has also been shown to be involved in the regulation of cell signaling pathways, which are responsible for the transduction of signals from the cell surface to inside the cell.

GOSR1 is also of interest as a potential drug target. The ability of GOSR1 to modulate muscle physiology and metabolism makes it an attractive target for drug development. Additionally, GOSR1's unique catalytic mechanism and its involvement in several physiological processes also make it a promising target for drug development.

One of the main advantages of GOSR1 as a drug target is its ease of manipulation. The catalytic mechanism of GOSR1 allows for the targeted phosphorylation of specific amino acid residues, which can be modified by small molecules. This makes it possible to design small molecules that specifically interact with GOSR1 and modulate its function. Additionally, the GOSR1 gene is well-studied, which has allowed researchers to identify several potential drug targets.

Another advantage of GOSR1 as a drug target is its potential impact on multiple muscle-related conditions. The regulation of muscle protein synthesis and degradation is involved in several muscle-related conditions, including muscle dystrophy, myopathies, and muscle-related pain. By modulating GOSR1 function, researchers have the potential to develop new treatments for these conditions.

In conclusion, GOSR1 is a protein that is of interest as a drug target due to its unique catalytic mechanism and its involvement in several physiological processes. The regulation of muscle protein synthesis and degradation, as well as muscle force production, is a critical role for GOSR1, and its potential as a drug target is substantial. Further research is needed to fully understand the impact of GOSR1 on muscle physiology and metabolism, as well as its potential as a drug target.

Protein Name: Golgi SNAP Receptor Complex Member 1

Functions: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi

More Common Targets

GOSR2 | GOT1 | GOT1-DT | GOT1L1 | GOT2 | GOT2P1 | GP1BA | GP1BB | GP2 | GP5 | GP6 | GP9 | GPA33 | GPAA1 | GPALPP1 | GPAM | GPANK1 | GPAT2 | GPAT3 | GPAT4 | GPATCH1 | GPATCH11 | GPATCH2 | GPATCH2L | GPATCH3 | GPATCH4 | GPATCH8 | GPBAR1 | GPBP1 | GPBP1L1 | GPC1 | GPC1-AS1 | GPC2 | GPC3 | GPC4 | GPC5 | GPC5-AS1 | GPC5-AS2 | GPC6 | GPC6-AS1 | GPC6-AS2 | GPCPD1 | GPD1 | GPD1L | GPD2 | GPER1 | GPHA2 | GPHB5 | GPHN | GPI | GPI transamidase complex | GPI-GlcNAc transferase complex | GPIHBP1 | GPKOW | GPLD1 | GPM6A | GPM6B | GPN1 | GPN2 | GPN3 | GPNMB | GPR101 | GPR107 | GPR108 | GPR119 | GPR12 | GPR132 | GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180