Target Name: GPBAR1
NCBI ID: G151306
Other Name(s): G-protein coupled bile acid receptor 1 | G-protein coupled bile acid receptor BG37 (TGR5) | GPCR19 | G-protein coupled receptor GPCR19 | G-protein coupled bile acid receptor BG37 | hGPCR19 | M-BAR | GPBAR_HUMAN | Membrane bile acid receptor | G protein-coupled bile acid receptor 1 | GPR131 | G protein-coupled bile acid receptor 1, transcript variant 1 | GPBAR1 variant 1 | TGR5 | membrane-type receptor for bile acids | GPBAR1 variant 3 | G protein-coupled bile acid receptor 1, transcript variant 3 | hBG37 | membrane bile acid receptor | BG37 | Membrane-type receptor for bile acids | GPCR

GPBARs as Potential Drug Targets for Diabetes

G-protein coupled bile acid receptors (GPBARs) are a family of transmembrane proteins that play an essential role in bile acid signaling. They are involved in the regulation of bile acid transport, excretion, and metabolism, and are expressed in various tissues, including the liver, small intestine, and pancreas. GPBARs are involved in a wide range of physiological processes, including the digestion and absorption of nutrients, the regulation of water and electrolyte balance, and the maintenance of cellular homeostasis.

Recent studies have identified GPBARs as potential drug targets or biomarkers for various diseases, including diabetes, obesity, and neurodegenerative disorders. This article will provide an overview of GPBARs, their functions, and the potential of targeting them for therapeutic purposes.

Understanding GPBARs

GPBARs are a subfamily of the G protein-coupled receptor (GPCR) family. They are characterized by the presence of a transmembrane domain, a cytoplasmic domain, and an extracellular domain that is involved in protein-protein interactions and modulation of intracellular signaling pathways. GPBARs are involved in the regulation of various physiological processes, including bile acid transport, excretion, and metabolism.

GPBARs are involved in the uptake and internalization of bile acids across the membrane of the cell. Bile acids are essential for the digestion and absorption of nutrients, and they play a crucial role in maintaining cellular homeostasis. However, the transport and excretion of bile acids are also critical for maintaining the physiological balance of these molecules. GPBARs are involved in these processes by regulating the number of bile acids that are taken up by the cell and the rate at which they are excreted.

GPBARs are also involved in the regulation of water and electrolyte balance. They are involved in the regulation of sodium and potassium homeostasis, as well as the regulation of water transport. They do this by modulating the activity of ion channels, such as the Na+, K+, and Cl- channels, which are involved in the regulation of ion and water transport.

In addition to their involvement in bile acid and water homeostasis, GPBARs are also involved in the regulation of cellular signaling pathways. They are involved in the regulation of cell growth, apoptosis, and inflammation. They do this by modulating the activity of various intracellular signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway.

Identification of potential drug targets

GPBARs have been identified as potential drug targets for a wide range of diseases. They are involved in the regulation of various physiological processes, including bile acid transport, excretion, and metabolism, and are involved in the regulation of cell growth, apoptosis, and inflammation. This makes them an attractive target for therapeutic interventions aimed at improving the health and well-being of individuals.

In the context of diabetes, GPBARs have been identified as potential drug targets for their role in the regulation of bile acid transport and metabolism. Diabetes is a chronic metabolic disorder that is characterized by the failure of the body to produce or use insulin in an efficient manner. Insulin is a hormone that regulates blood sugar levels, and it is essential for maintaining cellular homeostasis. However, the regulation of bile acid transport and metabolism is also critical for maintaining the physiological balance of these molecules. GPBARs are involved in this process, and their regulation is disrupted in diabetes.

Studies have shown that GPBARs are involved in the regulation of bile acid transport and metabolism in the liver. They are expressed in the liver and are involved in the uptake and internalization of bile acids. In addition, GPBARs are involved in the regulation of the excretion of bile acids from the liver.

Protein Name: G Protein-coupled Bile Acid Receptor 1

Functions: Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids

More Common Targets

GPBP1 | GPBP1L1 | GPC1 | GPC1-AS1 | GPC2 | GPC3 | GPC4 | GPC5 | GPC5-AS1 | GPC5-AS2 | GPC6 | GPC6-AS1 | GPC6-AS2 | GPCPD1 | GPD1 | GPD1L | GPD2 | GPER1 | GPHA2 | GPHB5 | GPHN | GPI | GPI transamidase complex | GPI-GlcNAc transferase complex | GPIHBP1 | GPKOW | GPLD1 | GPM6A | GPM6B | GPN1 | GPN2 | GPN3 | GPNMB | GPR101 | GPR107 | GPR108 | GPR119 | GPR12 | GPR132 | GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4 | GPR42 | GPR45 | GPR50 | GPR52 | GPR55 | GPR6 | GPR61 | GPR62