Target Name: GPBP1
NCBI ID: G65056
Other Name(s): GPBP1 variant 4 | Vasculin (isoform 3) | vascular wall-linked protein | GPBP | GC-rich promoter binding protein 1 | GPBP1 variant 1 | Vascular wall-linked protein | GPBP1 variant 2 | GC-rich promoter-binding protein 1 | DKFZp761C169 | GC-rich promoter binding protein 1, transcript variant 3 | GPBP1_HUMAN | GPBP1 variant 3 | GC-rich promoter binding protein 1, transcript variant 4 | SSH6 | Vasculin (isoform 1) | GC-rich promoter binding protein 1, transcript variant 1 | VASCULIN | Vasculin (isoform 2) | GC-rich promoter binding protein 1, transcript variant 2 | Vasculin (isoform 4) | Vasculin

GPBP1-4: Potential Drug Targets for Neurological Disorders

GPBP1, also known as GPBP1 variant 4, is a gene that encodes a protein involved in the blood-brain barrier (BBB). The BBB is a specialized barrier that separates the brain from the surrounding blood vessels, and it plays a crucial role in protecting the brain from harmful substances and ensuring efficient delivery of essential nutrients. Mutations in the GPBP1 gene have been linked to various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia.

GPBP1 variants are cDNA variants that occur in the gene that encodes the GPBP1 protein. These variants can have different effects on the structure and/or function of the protein. Variant 4, also known as GPBP1-4, is one of the most well-studied GPBP1 variants. It is a single-base polymorphism, which means that it only differs from the reference sequence at a single nucleotide position.

Studies have shown that GPBP1-4 is involved in the regulation of cell-cell adhesion, a critical process that plays a role in the development and maintenance of tissues and organs. The GPBP1 protein is known to be involved in the formation of tight junctions, which are specialized junctions that mediate the transfer of electrical signals between cells. In addition, GPBP1 is involved in the regulation of cell-cell adhesion by promoting the formation of tight junctions and inhibiting the formation of tight junctions that are not necessary for cell-cell communication.

GPBP1-4 has also been shown to be involved in the regulation of cell-cell adhesion in the developing brain. Studies have shown that GPBP1-4 is involved in the formation of tight junctions in the cerebral cortical neurons, which are important for the development and function of the brain. In addition, GPBP1-4 has been shown to be involved in the regulation of the activity of neurons in the prefrontal cortical region, which is important for various higher-order cognitive functions.

In addition to its role in cell-cell adhesion, GPBP1-4 has also been shown to be involved in the regulation of inflammation. Studies have shown that GPBP1-4 is involved in the regulation of the production of pro-inflammatory cytokines, which play a role in the development of inflammatory diseases. In addition, GPBP1-4 has been shown to be involved in the regulation of the production of anti-inflammatory cytokines, which play a role in the regulation of immune responses.

In conclusion, GPBP1-4 is a gene that encodes a protein involved in the blood-brain barrier. Studies have shown that this protein is involved in the regulation of cell-cell adhesion, the regulation of inflammation, and the regulation of cell-cell communication in the developing brain. These functions are important for the development and maintenance of tissues and organs, and mutations in the GPBP1 gene have been linked to various neurological and psychiatric disorders. Therefore, GPBP1-4 may be a drug target or biomarker for the development of new treatments for these disorders.

Protein Name: GC-rich Promoter Binding Protein 1

Functions: Functions as a GC-rich promoter-specific transactivating transcription factor

More Common Targets

GPBP1L1 | GPC1 | GPC1-AS1 | GPC2 | GPC3 | GPC4 | GPC5 | GPC5-AS1 | GPC5-AS2 | GPC6 | GPC6-AS1 | GPC6-AS2 | GPCPD1 | GPD1 | GPD1L | GPD2 | GPER1 | GPHA2 | GPHB5 | GPHN | GPI | GPI transamidase complex | GPI-GlcNAc transferase complex | GPIHBP1 | GPKOW | GPLD1 | GPM6A | GPM6B | GPN1 | GPN2 | GPN3 | GPNMB | GPR101 | GPR107 | GPR108 | GPR119 | GPR12 | GPR132 | GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4 | GPR42 | GPR45 | GPR50 | GPR52 | GPR55 | GPR6 | GPR61 | GPR62 | GPR63