Target Name: GOT2
NCBI ID: G2806
Other Name(s): glutamic-oxaloacetic transaminase 2, mitochondrial | Plasma membrane-associated fatty acid-binding protein | kynurenine aminotransferase 4 | KATIV | Glutamate oxaloacetate transaminase 2 | Kynurenine--oxoglutarate transaminase 4 | kynurenine aminotransferase IV | Kynurenine aminotransferase IV | mitAAT | transaminase A | fatty acid-binding protein | mAspAT | KAT4 | Transaminase A | glutamate oxaloacetate transaminase 2 | GOT2 variant 1 | kynurenine--oxoglutarate transaminase 4 | Kynurenine aminotransferase 4 | kynurenine--oxoglutarate transaminase IV | FABP-1 | AATM_HUMAN | Aspartate aminotransferase, mitochondrial (isoform 1) | glutamic-oxaloacetic transaminase 2 | KYAT4 | Fatty acid-binding protein | DEE82 | aspartate transaminase 2 | FABPpm | Glutamic-oxaloacetic transaminase 2, transcript variant 1 | Aspartate aminotransferase, mitochondrial | Kynurenine--oxoglutarate transaminase IV | plasma membrane-associated fatty acid-binding protein | Aspartate transaminase | aspartate aminotransferase 2

GOT2: The Double-Blinded Trail-Making Gene

GOT2, or glutamic-oxaloacetic transaminase 2, is a protein that is expressed in most tissues of the body, including the brain, heart, and kidneys. It is a crucial enzyme that plays a significant role in the metabolism of energy and participates in the detoxification process. The GOT2 gene has been well-studied, and its role in various physiological processes has been well-established. However, recent studies have also found that GOT2 may have potential as a drug target or biomarker.

The GOT2 gene was first identified in 1995 by researchers using DNA sequencing technology. Since then, numerous studies have demonstrated that GOT2 is involved in a wide range of cellular processes, including metabolism, inflammation, and stress resistance. GOT2 has been shown to be involved in the metabolism of essential amino acids, such as glutamate and cysteine, as well as in the detoxification of harmful substances like lead and arsenic.

One of the most significant functions of GOT2 is its role in the detoxification process. GOT2 has been shown to have a high affinity for arsenic, a toxic compound that can cause serious health problems if ingested in high concentrations. Studies have shown that GOT2 can effectively reduce arsenic toxicity in animals by increasing the levels of glutathione, a protein that is known for its ability to detoxify harmful substances.

In addition to its role in detoxification, GOT2 has also been shown to be involved in the regulation of cellular stress responses. Studies have shown that GOT2 can modulate the activity of stress-responsive genes, including those involved in inflammation and stress resistance. This suggests that GOT2 may play a key role in the regulation of cellular stress responses and the potential health consequences of chronic stress.

GOT2 has also been shown to be involved in the metabolism of essential amino acids, such as glutamate and cysteine. Studies have shown that GOT2 can convert glutamate, a crucial amino acid involved in muscle function and nerve development, to cysteine, a less essential amino acid that can be used to synthesize other important molecules like proteins and drugs. This suggests that GOT2 may be involved in the regulation of protein synthesis and may have potential as a drug target for diseases caused by disruptions in protein synthesis.

Furthermore, GOT2 has been associated with various diseases, including neurodegenerative disorders, cancer, and cardiovascular disease. Studies have shown that individuals with certain genetic variations in the GOT2 gene are at increased risk for developing these diseases. This suggests that GOT2 may be a promising biomarker for the development of these diseases and may have potential as a drug target.

In conclusion, GOT2 is a protein that has been well-studied for its role in various cellular processes. Its role in the detoxification process, regulation of protein synthesis, and involvement in stress responses make it a promising candidate as a drug target or biomarker. Further research is needed to fully understand the potential of GOT2 as a drug target or biomarker and to determine its utility in the clinic.

Protein Name: Glutamic-oxaloacetic Transaminase 2

Functions: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids

More Common Targets

GOT2P1 | GP1BA | GP1BB | GP2 | GP5 | GP6 | GP9 | GPA33 | GPAA1 | GPALPP1 | GPAM | GPANK1 | GPAT2 | GPAT3 | GPAT4 | GPATCH1 | GPATCH11 | GPATCH2 | GPATCH2L | GPATCH3 | GPATCH4 | GPATCH8 | GPBAR1 | GPBP1 | GPBP1L1 | GPC1 | GPC1-AS1 | GPC2 | GPC3 | GPC4 | GPC5 | GPC5-AS1 | GPC5-AS2 | GPC6 | GPC6-AS1 | GPC6-AS2 | GPCPD1 | GPD1 | GPD1L | GPD2 | GPER1 | GPHA2 | GPHB5 | GPHN | GPI | GPI transamidase complex | GPI-GlcNAc transferase complex | GPIHBP1 | GPKOW | GPLD1 | GPM6A | GPM6B | GPN1 | GPN2 | GPN3 | GPNMB | GPR101 | GPR107 | GPR108 | GPR119 | GPR12 | GPR132 | GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20