Target Name: GPATCH8
NCBI ID: G23131
Other Name(s): G patch domain-containing protein 8 | G-patch domain containing 8, transcript variant 1 | GPTC8_HUMAN | G patch domain-containing protein 8 (isoform 1) | G-patch domain containing 8 | GPATCH8 variant 1 | GPATC8 | KIAA0553

GPATCH8: A Potential Drug Target and Biomarker for diseases

GPATCH8, also known as Patchin, is a protein located in the N-end region of the neural transmission factor (NGT) gene in humans. It plays a crucial role in the development and progression of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.GPATCH8 has been identified as a potential drug target and biomarker for these diseases due to its unique structure, expression, and function.

Structure and Function

GPATCH8 is a 21-kDa protein that contains 109 amino acid residues. It is characterized by a N-end region that is rich in conserved putative transmembrane domains (TMDs) and a C-end region that contains a unique N-end insertion of a 24 amino acid residue helix. The N-end region is responsible for the protein's ability to interact with various signaling pathways, including the TGF-β pathway.

GPATCH8 functions as a negative regulator of the TGF-β pathway by inhibiting the activity of the transcription factor, transforming growth factor 尾 (TGF-β). The TGF-β pathway is a well-established regulator of cell growth, differentiation, and survival, and is involved in the development and progression of many diseases, including neurodegenerative diseases. By inhibiting TGF-β activity, GPATCH8 protects against neurodegeneration and promotes neuroplasticity, which may have potential therapeutic applications in neurodegenerative diseases.

Expression and Localization

GPATCH8 is highly expressed in various tissues and organs, including brain, heart, and muscle. It is predominantly expressed in the brain, where it is present at levels of 1-10% of total protein in the brain. GPATCH8 is also expressed in other tissues, including heart and muscle, but at much lower levels.

The brain is a key organ for the regulation of TGF-β activity, and the levels of GPATCH8 in the brain are consistent with its function as a negative regulator of the TGF-β pathway. Additionally, the brain contains high levels of neurotransmitters, such as dopamine and glutamate, which are known to be regulated by TGF-β. Therefore, manipulation of GPATCH8 levels in the brain may have a therapeutic impact on neurotransmitter function and the development of neurodegenerative diseases.

Drug Target Potential

GPATCH8 has been identified as a potential drug target for neurodegenerative diseases due to its unique structure and function. The inhibition of TGF-β activity by GPATCH8 provides a new mechanism for targeting neurodegenerate diseases. Several small molecules have been shown to interact with GPATCH8 and inhibit TGF-β activity. Therefore, GPATCH8 may be a promising target for the development of new therapies for neurodegenerative diseases.

Biomarker Potential

GPATCH8 has also been identified as a potential biomarker for neurodegenerative diseases. The levels of GPATCH8 in various tissues, including brain, heart, and muscle, may be used as a diagnostic or monitoring tool for neurodegenerative diseases. Additionally, the levels of GPATCH8 may be used as a target for diagnostic biomarkers, such as protein-based assays or genetic markers.

Conclusion

GPATCH8 is a protein that has the potential to be a drug target and biomarker for neurodegenerative diseases. Its unique structure and function, as well as its expression in the brain, make it an attractive target for the development of new therapies. Further research is needed to fully understand the role of GPATCH8 in neurodegenerative diseases and to develop new diagnostic tools for these conditions.

Protein Name: G-patch Domain Containing 8

More Common Targets

GPBAR1 | GPBP1 | GPBP1L1 | GPC1 | GPC1-AS1 | GPC2 | GPC3 | GPC4 | GPC5 | GPC5-AS1 | GPC5-AS2 | GPC6 | GPC6-AS1 | GPC6-AS2 | GPCPD1 | GPD1 | GPD1L | GPD2 | GPER1 | GPHA2 | GPHB5 | GPHN | GPI | GPI transamidase complex | GPI-GlcNAc transferase complex | GPIHBP1 | GPKOW | GPLD1 | GPM6A | GPM6B | GPN1 | GPN2 | GPN3 | GPNMB | GPR101 | GPR107 | GPR108 | GPR119 | GPR12 | GPR132 | GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18 | GPR180 | GPR182 | GPR183 | GPR19 | GPR199P | GPR20 | GPR21 | GPR22 | GPR25 | GPR26 | GPR27 | GPR3 | GPR31 | GPR32 | GPR33 | GPR34 | GPR35 | GPR37 | GPR37L1 | GPR39 | GPR4 | GPR42 | GPR45 | GPR50 | GPR52 | GPR55 | GPR6 | GPR61