Target Name: GORASP1
NCBI ID: G64689
Other Name(s): Golgi peripheral membrane protein p65 | golgi reassembly stacking protein 1 | Golgi reassembly-stacking protein 1 (isoform 1) | Golgi reassembly stacking protein 1, transcript variant 1 | Golgi reassembly and stacking protein, 65 kDa | golgi reassembly-stacking protein of 65 kDa | Golgi reassembly-stacking protein of 65 kDa | GOLPH5 | Golgi phosphoprotein 5 | GORS1_HUMAN | Golgi reassembly and stacking protein 1 | golgi reassembly stacking protein 1, 65kDa | P65 | Golgi reassembly-stacking protein 1 | GRASP65 | GORASP1 variant 1

GORASP1: A Potential Drug Target and Biomarker for Golgi Peripheral Membrane Protein p65

Golgi peripheral membrane protein (GPMP) p65 is a key component of the Golgi system, which is a network of specialized vesicles that play a crucial role in cell signaling and excretion. p65 is a transmembrane protein that is expressed in various cell types, including neurons , endothelial cells, and epithelial cells. Its function is essential in the regulation of cell signaling pathways, including cell adhesion, migration, and the regulation of the blood-brain barrier.

GPMP p65 has also been shown to play a key role in the development and progression of various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression. Its dysfunction has been associated with the misfolding of p65, which has led to the formation of aggregates that can cause neurotoxicity and contribute to the development of neurodegenerative diseases.

GORASP1, also known as GLT-1, is a protein that is expressed in various cell types and has been shown to interact with p65. GORASP1 has been shown to modulate the activity of p65, including its functions in cell signaling and the regulation of the blood-brain barrier. GORASP1 has also been shown to play a key role in the regulation of neurodegenerative diseases, including the misfolding of p65 and the formation of neurotoxicity.

GORASP1 is a potential drug target for the treatment of various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression. Its interaction with p65 and its role in the regulation of neurodegenerative diseases make it an attractive target for drug development.

GORASP1 is also a potential biomarker for the diagnosis and monitoring of neurodegenerative diseases. Its expression has been shown to be affected by various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression. Therefore, its levels can be used as a diagnostic or monitoring tool for these disorders.

In conclusion, GORASP1 is a protein that has the potential to be a drug target and biomarker for the treatment of various neurological and psychiatric disorders. Its interaction with p65 and its role in the regulation of neurodegenerative diseases make it an attractive target for drug development. Further research is needed to fully understand the role of GORASP1 in the treatment of neurodegenerative diseases and its potential as a biomarker.

Protein Name: Golgi Reassembly Stacking Protein 1

Functions: Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936)

More Common Targets

GORASP2 | GOSR1 | GOSR2 | GOT1 | GOT1-DT | GOT1L1 | GOT2 | GOT2P1 | GP1BA | GP1BB | GP2 | GP5 | GP6 | GP9 | GPA33 | GPAA1 | GPALPP1 | GPAM | GPANK1 | GPAT2 | GPAT3 | GPAT4 | GPATCH1 | GPATCH11 | GPATCH2 | GPATCH2L | GPATCH3 | GPATCH4 | GPATCH8 | GPBAR1 | GPBP1 | GPBP1L1 | GPC1 | GPC1-AS1 | GPC2 | GPC3 | GPC4 | GPC5 | GPC5-AS1 | GPC5-AS2 | GPC6 | GPC6-AS1 | GPC6-AS2 | GPCPD1 | GPD1 | GPD1L | GPD2 | GPER1 | GPHA2 | GPHB5 | GPHN | GPI | GPI transamidase complex | GPI-GlcNAc transferase complex | GPIHBP1 | GPKOW | GPLD1 | GPM6A | GPM6B | GPN1 | GPN2 | GPN3 | GPNMB | GPR101 | GPR107 | GPR108 | GPR119 | GPR12 | GPR132 | GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179