Target Name: GORASP2
NCBI ID: G26003
Other Name(s): GORS2_HUMAN | GRS2 | Golgi reassembly-stacking protein 2 (isoform 1) | Golgi reassembly-stacking protein 2 | Golgi reassembly-stacking protein of 55 kDa | GORASP2 variant 1 | p59 | GOLPH6 | golgi reassembly stacking protein 2, 55kDa | Golgi reassembly stacking protein 2, transcript variant 1 | Golgi phosphoprotein 6 | golgi phosphoprotein 6 | GRASP55 | P59 | golgi reassembly stacking protein 2

GORASP2: A Potential Drug Target and Biomarker

GORASP2, also known as GORS2-HUMAN, is a protein that is expressed in various tissues of the human body, including the brain, heart, and lungs. It is a part of the GORASP family of proteins, which are involved in the regulation of cell signaling pathways. GORASP2 has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and respiratory disorders.

The GORASP2 protein is composed of 115 amino acid residues and has a molecular weight of 13.9 kDa. It is a monocystic protein that is expressed in the brain, heart, and lungs, and its levels are regulated by various factors, including growth factors, cytokines, and chemokines. GORASP2 is involved in the regulation of cell signaling pathways, including the TGF-β pathway, which is involved in the regulation of cell growth, differentiation, and survival.

GORASP2 has been shown to play a role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and respiratory disorders. For example, studies have shown that GORASP2 is involved in the regulation of cell signaling pathways in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. GORASP2 has also been shown to be involved in the regulation of cell signaling pathways in cancer, including the regulation of cell proliferation and apoptosis.

In addition to its potential role in disease, GORASP2 has also been identified as a potential drug target. Studies have shown that GORASP2 can be targeted by small molecules, including inhibitors of tyrosine kinase activity, which are commonly used as therapeutic agents for various diseases. Additionally, GORASP2 can be targeted by small molecules that can modulate its expression level, such as RNA interference and CRISPR/Cas9-based approaches.

GORASP2 has also been shown to be a potential biomarker for various diseases. Studies have shown that GORASP2 can be used as a potential biomarker for cancer, neurodegenerative diseases, and respiratory disorders. For example, GORASP2 has been shown to be expressed in various tissues of cancer cells, and its levels can be used as a biomarker for cancer diagnosis and treatment. Additionally, GORASP2 has been shown to be involved in the regulation of cell signaling pathways in neurodegenerative diseases, and its levels can be used as a biomarker for neurodegenerative diseases. Finally, GORASP2 has been shown to be involved in the regulation of cell signaling pathways in respiratory disorders, and its levels can be used as a biomarker for respiratory disorders.

In conclusion, GORASP2 is a protein that is involved in the regulation of cell signaling pathways and has been identified as a potential drug target and biomarker for various diseases. Further research is needed to fully understand the role of GORASP2 in disease and to develop effective therapeutic agents that can target it. However, the potential of GORASP2 as a drug target and biomarker makes it an important area of research for the development of new treatments for various diseases.

Protein Name: Golgi Reassembly Stacking Protein 2

Functions: Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075). May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262)

More Common Targets

GOSR1 | GOSR2 | GOT1 | GOT1-DT | GOT1L1 | GOT2 | GOT2P1 | GP1BA | GP1BB | GP2 | GP5 | GP6 | GP9 | GPA33 | GPAA1 | GPALPP1 | GPAM | GPANK1 | GPAT2 | GPAT3 | GPAT4 | GPATCH1 | GPATCH11 | GPATCH2 | GPATCH2L | GPATCH3 | GPATCH4 | GPATCH8 | GPBAR1 | GPBP1 | GPBP1L1 | GPC1 | GPC1-AS1 | GPC2 | GPC3 | GPC4 | GPC5 | GPC5-AS1 | GPC5-AS2 | GPC6 | GPC6-AS1 | GPC6-AS2 | GPCPD1 | GPD1 | GPD1L | GPD2 | GPER1 | GPHA2 | GPHB5 | GPHN | GPI | GPI transamidase complex | GPI-GlcNAc transferase complex | GPIHBP1 | GPKOW | GPLD1 | GPM6A | GPM6B | GPN1 | GPN2 | GPN3 | GPNMB | GPR101 | GPR107 | GPR108 | GPR119 | GPR12 | GPR132 | GPR135 | GPR137 | GPR137B | GPR137C | GPR139 | GPR141 | GPR142 | GPR143 | GPR146 | GPR148 | GPR149 | GPR15 | GPR150 | GPR151 | GPR152 | GPR153 | GPR155 | GPR156 | GPR157 | GPR158 | GPR158-AS1 | GPR15LG | GPR160 | GPR161 | GPR162 | GPR17 | GPR171 | GPR173 | GPR174 | GPR176 | GPR179 | GPR18